JCM, Free Full-Text

Por um escritor misterioso

Descrição

Non-syndromic tooth agenesis (ns-TA) is one of the most common dental anomalies characterized by the congenital absence of at least one permanent tooth (excluding third molars). Regarding the essential role of genetic factors in ns-TA aetiology, the present study aimed to identify novel pathogenic variants underlying hypodontia and oligodontia. In a group of 65 ns-TA patients and 127 healthy individuals from the genetically homogenous Polish population, the coding sequences of 423 candidate genes were screened using targeted next-generation sequencing. Pathogenic and likely pathogenic variants were identified in 37 (56.92%) patients, including eight nucleotide alternations of genes not previously implicated in ns-TA (CHD7, CREBBP, EVC, LEF1, ROR2, TBX22 and TP63). However, since only single variants were detected, future research is required to confirm and fully understand their role in the aetiology of ns-TA. Additionally, our results support the importance of already known ns-TA candidate genes (AXIN2, EDA, EDAR, IRF6, LAMA3, LRP6, MSX1, PAX9 and WNT10A) and provide additional evidence that ns-TA might be an oligogenic condition involving the cumulative effect of rare variants in two or more distinct genes.
JCM, Free Full-Text
Marshall JCM800 2203X 100-watt Tube Head
JCM, Free Full-Text
Central service technical manual : Free Download, Borrow, and Streaming : Internet Archive
JCM, Free Full-Text
JCM, Free Full-Text
JCM, Free Full-Text
JCM800 - SabroTone
JCM, Free Full-Text
Ucr Spss Get File - Colaboratory
JCM, Free Full-Text
Joseph's Classic Market
JCM, Free Full-Text
Tnm Elevation Get File - Colaboratory
JCM, Free Full-Text
JCM, Free Full-Text
JCM, Free Full-Text
JCM, Free Full-Text
de por adulto (o preço varia de acordo com o tamanho do grupo)