Cells, Free Full-Text
Por um escritor misterioso
Descrição
The neurovascular unit (NVU) is a conceptual framework that has been proposed to better explain the relationships between the neural cells and blood vessels in the human brain, focused mainly on the brain gray matter. The major components of the NVU are the neurons, astrocytes (astroglia), microvessels, pericytes, and microglia. In addition, we believe that oligodendrocytes should also be included as an indispensable component of the NVU in the white matter. Of all these components, astrocytes in particular have attracted the interest of researchers because of their unique anatomical location; these cells are interposed between the neurons and the microvessels of the brain. Their location suggests that astrocytes might regulate the cerebral blood flow (CBF) in response to neuronal activity, so as to ensure an adequate supply of glucose and oxygen to meet the metabolic demands of the neurons. In fact, the adult human brain, which accounts for only 2% of the entire body weight, consumes approximately 20–25% of the total amount of glucose and oxygen consumed by the whole body. The brain needs a continuous supply of these essential energy sources through the CBF, because there are practically no stores of glucose or oxygen in the brain; both acute and chronic cessation of CBF can adversely affect brain functions. In addition, another important putative function of the NVU is the elimination of heat and waste materials produced by neuronal activity. Recent evidence suggests that astrocytes play pivotal roles not only in supplying glucose, but also fatty acids and amino acids to neurons. Loss of astrocytic support can be expected to lead to malfunction of the NVU as a whole, which underlies numerous neurological disorders. In this review, we shall focus on historical and recent findings with regard to the metabolic contributions of astrocytes in the NVU.
Advancing synthetic biology through cell-free protein synthesis - ScienceDirect
Cells, Free Full-Text
An illustration of the full-duplex cell-free massive MIMO system.
Streptomyces cell-free systems for natural product discovery and engineering - ScienceDirect
HIV-1 cell-to-cell transmission and broadly neutralizing antibodies, Retrovirology
THE LIVES OF A CELL : LEWIS THOMAS : Free Download, Borrow, and Streaming : Internet Archive
Effect of calendar ageing on the cycle life of anode-free full-cells.
Towards reproducible cell-free systems
Antibodies, Free Full-Text
Cell-free Macromolecular Synthesis
PDF) Protein structural biology using cell-free platform from wheat germ
Extracellular histones, cell-free DNA, or nucleosomes: differences in immunostimulation
THE CELL : PAUL REVERE11 : Free Download, Borrow, and Streaming : Internet Archive
de
por adulto (o preço varia de acordo com o tamanho do grupo)
